Research Paper Volume 16, Issue 3 pp 2989—3006
Minocycline alleviates LPS-induced cognitive dysfunction in mice by inhibiting the NLRP3/caspase-1 pathway
Figure 2. Minocycline alleviated LPS-induced hippocampal injury and apoptosis. (A) Hippocampal tissues were stained with H&E solution to elucidate pathological alterations. The red arrows point to the inflammatory cells. (B–D) The expression levels of Bax and Bcl-2 in hippocampal tissues were detected by Western blot assay. Data were presented as mean ± SD, n = 5–6 mice per group; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. LPS group.