Research Paper Volume 16, Issue 4 pp 3955—3972
Protective effects of triptolide against oxidative stress in retinal pigment epithelium cells via the PI3K/AKT/Nrf2 pathway: a network pharmacological method and experimental validation
Figure 3. The underlying target of triptolide by network pharmacology analysis. (A) The chemical structure of TP. (B) The 417 intersection targets of TP against AMD (Venn diagram). (C) The crucial protein interaction network diagram. The larger the degree of the node in the graph, the darker the color and the larger the diameter of the node. (D) GO functional annotation for potential targets of TP on AMD. (E) KEGG enrichment analysis for potential targets of TP on AMD. (F) The molecular docking model of TP with PI3K and Nrf2.