Research Paper Advance Articles

Figure 1. Blood glucose change and insulin secretion after Oxt injection. (A) Change of blood glucose after Oxt (400 μg/kg) injection in wild type mice (left, n = 14, 15) and OxtR KO mice (right, n = 6, 6). (B) Changes of insulin levels after Oxt (400 μg/kg) injection in wild type mice (left, n = 5, 5) and OxtR KO mice (right, n = 5, 5). *: p < 0.05, **: p < 0.01, repeated measures two-way ANOVA followed by Sidak’s multiple range test. (C) Insulin secretion from isolated islets after 15 min from wild type and OxtR KO mice (open bar: control, grey bar: with Oxt, n = 5 wells for each condition). n.s: not significant. unpaired t-test. (D) Top panel: Insulin secretion from isolated WT mice islets after 30 min in control medium (open bar; 10 mM glucose: n = 5 wells, 20 mM glucose: n = 5 wells) and medium with Oxt (grey bar 10 mM glucose: n = 5 wells, 20 mM glucose: n = 6 wells). Bottom panel: Insulin secretion from isolated OxtR KO mice islets after 30 min in control medium (open bar; 10 mM glucose: n = 6 wells, 20 mM glucose: n = 8 wells) and medium with Oxt (grey bar10 mM glucose: n = 6 wells, 20 mM glucose: n = 8 wells). *: p < 0.05, unpaired t-test.