Research Paper Advance Articles

Figure 5. Ultrastructure of skeletal muscle (Gastrocnemius, Gas.) in Cisd1&2 DKO mice. (A) Architecture of soleus in WT mice. (B) Mitochondrial defects, necrosis and ER stress in Cisd1 KO soleus. (C) Mitochondrial defects, necrosis and ER stress in Cisd2 KO soleus. (D) Mitochondrial defects, myofibril degeneration, necrosis and ER stress in Cisd1&2 DKO soleus. (A–D) were shown at higher magnification (yellow squares) in Supplementary Figure 4. (A’–D’) are schematic presentations of the ultrastructure of the gastrocnemius shown in (A–D). Abbreviations: Ne: Nucleolus; NB: Nuclear envelope breakdown; MD: Mitochondrial defect; Myf: Myofibril; Myd: Myofibril degeneration; ERs: ER stress; ER: Endoplasmic Reticulum; L: Lysosome; MF: Myelin Figure; GD: Golgi degeneration. Mouse age, 5 weeks old.