Research Paper Advance Articles
Cisd1 synergizes with Cisd2 to modulate protein processing by maintaining mitochondrial and ER homeostasis
Figure 8. Schematic showing the alteration in biological processes identified in Cisd2 KO and Cisd1&2 DKO mice. (A) In wild type (WT) mice, the protein process, including translation, transportation, modification and degradation, is well-controlled by functional organelles. (B) Cisd2 deletion leads to organelle degeneration and autolysosome formation. (C) Ablation of both Cisd1 and Cisd2 has a synergistic effect that results in organelle breakdown and cell death.