Research Paper Advance Articles

Multi-omics analysis reveals metabolic disruptions in cardiac tissues of aging nonhuman primates with spontaneous type 2 diabetes

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Figure 2. Comparative analysis of cardiac tissue pathways in the OB and TM groups. (AC) Display the Gene Ontology (GO) analysis comparing the CON, OB, and TM groups in a pairwise manner, highlighting the most affected pathways. (D) Presents the differentially expressed typical extracellular matrix (ECM) related proteins across the CON, OB, and TM groups. (E) Illustrates the differential expression of serpin family members, which play a role in the regulation of the complement cascade. (F) Depicts the differentially expressed immune-related proteins in cardiac tissue among the CON, OB, and TM groups. (G) Shows the differentially expressed proteins related to metal ion metabolism in cardiac tissue across the CON, OB, and TM groups. (H) Profiles other differentially expressed proteins in cardiac tissue that were identified in the CON, OB, and TM groups.