Research Paper Advance Articles

DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders

class="figure-viewer-img"

Figure 1. Association between entropy, biological age, and biomarkers across neurological conditions. (A) Boxplots of entropy across different age groups (only significant P-values are annotated: P < 0.05 = *, P < 0.01 = **, P < 0.001 = ***). (B) Behavior of summed dolichol concentration through age, with a 95% confidence interval. (C) Predicted values of the models for all samples, including groups with no neurological disorder, autism, schizophrenia, and Down syndrome. (D) Boxplot comparing age acceleration across the different groups (Only significant P-values are annotated: P < 0.05 = *, P < 0.01 = **, P < 0.001 = ***).