Research Paper Advance Articles
Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression
Figure 1. Tert KO in myeloid cells suppresses the growth of breast, prostate, and pancreatic tumors. Tissues resected from LysM-Cre; Tertfl/fl (KO) and LysM-Cre; Tert+/+ (WT) littermates were analyzed once one of the groups developed a critical tumor burden. (A) E0771 tumor weight upon resection. (B) RM1 tumor weight upon resection. (C) KPC tumor weight upon resection. (D) Representative paraffin sections of KPC tumors stained with Trichrome (left) or subjected to CK19 and α-SMA IF (right) revealing epithelial cells (green arrows) and myofibroblasts (red arrows). Scale bar: 100 μm. Shown are mean +/- SEM, *P<0.05, Student’s t-test.