Research Paper Advance Articles
Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression
Figure 3. Tert KO in endothelial cells suppresses the growth of pancreatic tumors. Tissues resected from Tie2e-Cre; Tertfl/fl (KO) and Tie2e-Cre; Tert+/+ (WT) littermates were analyzed once one of the groups developed a critical tumor burden. (A) E0771 tumor weight upon resection. (B) RM1 tumor weight upon resection. (C) KPC tumor size weight upon resection. (D) Representative paraffin sections of KPC tumors stained with Trichrome (left) or subjected to CK19 and α-SMA IF (right) revealing epithelial cells (green arrows) and myofibroblasts (red arrows). Scale bar: 100 μm. Shown are mean +/- SEM, *P<0.05, Student’s t-test.