Research Paper Volume 17, Issue 6 pp 1511—1520
rDNA copy number variation and methylation from birth to sexual maturity
Figure 2. Age-related methylation changes of the rDNA UCE/CP in young individuals. The 139 healthy controls are indicated by red dots and 141 individuals with DD by blue dots. The Y axis shows the number of rDNA TU within a given methylation bin, the X axis indicates donor age, ranging from birth to < 20 years. The number of completely unmethylated (0%) promoter regions significantly increases with age, whereas the CN in the 1-10%, 11-20%, 21-30%, 31-40%, 41-50%, and 51-100% methylation bins is decreasing.