Research Paper Volume 17, Issue 6 pp 1544—1570
Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
Figure 5. E2F4 is positioned as an upstream controller in the regulatory cascade of KHDC4 and TRAF2. (A) Promoter assays outlining potential E2F4 binding sequences in the promoter sequences of TRAF2 and KHDC4. (B) The correlation of E2F4 with KHDC4 or TRAF2 in TCGA-PRAD. (C) The prognosis values of E2F4 on overall survival or disease-free survival rate in prostate cancer. (D) A Venn diagram analysis collecting molecules positively correlated to KHDC4 and TRAF2 in TCGA-PRAD datasets (Cell 2015, Firehose Legacy, and PanCancer Atlas). (E) Downstream effectors co-regulated by KHDC4 and TRAF2. (F) The correlation of downstream effectors of KHDC4 and TRAF2 with E2F4 in TCGA-PRAD.