Research Paper Advance Articles

Figure 3. Reduced diversity in aged microbiota of female B57Bl/6 mice. (A) Weighted UniFrac distance analysis depicting the variation in gut microbial composition at 3-, 12- and 18-month-old female C57BL/6 mice. (B) Shannon’s index of female C57BL/6 gut microbiota across different age groups. (C) Relative abundance of the top 22 genera in the gut microbiota of male mice at various ages. (D) The relative abundance of Akkermansia. (E) Prediction of differential metabolic pathways with Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Data in (B, D) were analyzed with Kruskal–Wallis followed by Dunn’s correction. Data are represented as mean ± SEM.