Figure 4. Alteration in cardiac metabolism in aged female C57BL/6 mice. (A) Schematic illustration of cardiac metabolism assessed with liquid chromatography mass spectrometry (LC-MS). (B) Partial Least Squares Discriminant Analysis (PLS-DA) depicting the variation in cardiac metabolites across different ages (3-, 12-, and 18 months). (C) Identification of differential metabolic pathways in cardiac tissues at 3- and 18-month of age. (D) Analysis of differential cardiac metabolites presented at 3- and 18-month of age.