Research Paper Volume 17, Issue 7 pp 1721—1745

Association of DNA methylation age acceleration with digital clock drawing test performance: the Framingham Heart Study

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Figure 1. Association between dCDT scores and DNAm age acceleration in 1789 participants of the FHS. The dCDT total score includes command task composite scores and copy task composite scores. DNA methylation age acceleration was obtained by regressing DNAm age metrics on chronological age. We conducted association analysis between standardized DNAm age acceleration and the dCDT total score, adjusted for age, self−reported sex, education and cell counts. The numbers inside each cell represent the P−values of the associations. The color represents the change in dCDT scores corresponding to a one SD increase in DNAm age acceleration.