Review Volume 17, Issue 7 pp 1881—1907

Figure 1. The RecQ helicase family in human. The RecQ helicase family contains five members in humans. The helicase core containing a DEAD-/DEXH-/DEAH-like helicase (red box) and a C-terminal helicase domain (pink box) is conserved in all of the family members. The RQC domain (yellow box) is present in RECQL, BLM and WRN helicases. The HRDC domain (green box) is found in BLM and WRN only. The zinc-binding domain (blue box) is conserved in RECQL, BLM, WRN, and RECQL5. The exonuclease domain (purple grey box) is unique to WRN, whereas the N-terminal domain (light blue) is unique to BLM, and the mitochondrial localization sequence (brown box) is unique to RECQL4. Image is created by Illustrator for Biological Sequences (IBS) 2.0.