Review Volume 17, Issue 7 pp 1881—1907

Figure 2. Conceptual framework illustrating how loss of WRN leads to the hallmarks of aging. Loss of WRN helicase results in alterations in different cellular and molecular processes (circles in the inner zone). These processes are linked to the known hallmarks of aging (circles in the outer zone) [173]. For instance, impaired DNA repair is associated with genome instability, whereas reduced proliferation and premature senescence are connected to stem cell exhaustion.