Research Paper Advance Articles

Figure 2. Spatial memory analyses of Tg2576 mice treated with blood from old and young wild type mice. The Barnes maze test was applied to all mice included in this study. (A) Average latency to the escape chamber for the training trials sessions over 5 days, as described in Materials and Methods. (B) Quantitative analysis of the short-term memory (STM) latency. (C) Quantitative analysis of the long-term memory (LTM) latency. (D) Quantitative analysis of the STM time-in-quadrant parameter. (E) Quantitative analysis of the LTM time-in-quadrant parameters. N = 6–7/group, (random mix of males and females; young donor group: 3M/3F; old donor group: 3M/4F). Sex was not included as a variable in statistical analyses. Data values are expressed as means ± SEM. Data in (A) were analyzed using repeated/measures ANOVA. Data in (B) and (D) were analyzed using Student’s t-test. Data in (C) and (E) were analyzed using the Mann-Whitney U-test. ^*p < 0.05.