Research Paper Advance Articles
Establishment of an optimized chemotherapy-induced mouse model for premature ovarian failure: protocol and findings
Figure 9. Confirmation of natural recovery after 4 weeks of establishment POF model in NMRI female 6-8weeks mice. Histological confirmation of POF phenotype at four weeks post-induction with CTX (100 mg/kg) + Bu (20 mg/kg). Findings demonstrate persistent follicular depletion and stromal atrophy with no signs of natural follicular recovery.