Research Paper Advance Articles
Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence
Figure 1. Methylglyoxal (MGO) induces glycation stress which can be prevented by glycation lowering (Gly-Low) compound supplementation. (A) Treatment paradigm for MGO and Gly-Low supplementation in 3-month-old male mice. (B) Aortic PWV measured after intervention (n=7–10/group). (C) Plasma MGH-1 levels in male mice that received normal/Gly-Low chow with MGO supplemented in water (n=9/group). One-way ANOVA was used for panel (B), and an unpaired t-test was performed for panel (C). All values are in mean ± SEM, *p<0.05 vs. control; ♦p<0.05 vs. MGO alone.