Research Paper Advance Articles
Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence
Figure 5. MGO-induced glycation stress can increase cellular senescence. (A) Senescence-associated β-galactosidase staining for HAECs treated with DOXO/MGO/MGH-1 with or without Gly-Low supplementation. (B) mRNA expression of various senescence-associated genes. All data were analyzed using two-way ANOVA, as the analysis included both the treatment condition (control, DOXO, MGO, MGH-1) and the second factor (with or without Gly-Low). All values are in mean ± SEM, *p<0.05 vs. control (–Gly-Low); ♦p<0.05 vs. (–Gly-Low) of the same condition.