Research Paper Advance Articles
Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence
Figure 6. Gly-Low supplementation mitigates DOXO-induced aortic stiffening. (A) Aortic elastic modulus in young intervention-naïve male mouse aortas after 48-hour incubation with DOXO/Gly-Low (n=8/group). (B) Aortic elastic modulus in young intervention-naïve male mouse aortas after 48-hour incubation with DOXO/Gly-Low in the absence/presence of a Glo-1 inhibitor (n=9/group). All data were analyzed using paired T-test, as different media conditions were tested on aortas obtained from the same mouse. All values are in mean ± SEM, *p<0.05 vs. control (No DOXO/No Gly-Low); ♦p<0.05 vs. DOXO alone; ^p<0.05 vs. DOXO+Gly-Low.