Research Paper Advance Articles
CD47 antisense oligonucleotide treatment improves glucose homeostasis and alleviates dyslipidemia in aged male mice
Figure 1. CD47 ASO treatment reduced visceral fat mass in aged male mice. (A) Experimental design. Twenty-month-old male C57BL/6J mice were fed a normal chow diet and treated with 25 μg/g of control ASO or CD47 ASO twice per week for 10 weeks; (B) Body weight; (C) Body composition was measured by EchoMRI; (D) Tissue weights were measured during collection. Data are represented as mean ± SEM (n = 6 mice/group). *P < 0.05 compared to control ASO. Abbreviations: pWAT: peri-renal visceral white adipose tissue; eWAT: epididymal white adipose tissue; sWAT: subcutaneous white adipose tissue.