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Research Paper Volume 17, Issue 12 pp 2950—2988

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

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Figure 3. Chromosomal distribution of age-associated DMCs in sperm. Miami plot of age-associated differentially methylated CpG sites (DMCs), shown by direction of change (Delta β >0 relates to an increase in number of sperm cells that are methylated, Delta β <0 means a decrease in number of sperm cells that are methylated). Dashed line: no change (Δβ = 0). Delta β-values are calculated from M-values, as shown in the methods section Δβ=2(M0+delta M)1+2(M0+delta M)−2M01+2M0. Significant DMCs correspond to FDR <0.05. Blue dots are sites allocated to imprinted genes, listed in the Geneimprint database.