Research Paper Volume 17, Issue 12 pp 2950—2988
Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring
Figure 5. Functional genomic distribution of CpGs within 450K array and age-associated DMCs. (A) Percentages of CpGs by functional genomic region are displayed; by promoter, 1stExon, 5′UTR, 3′UTR, body, and intergenic regions. CpG sites allocated to multiple regions are reported as a separate category. (A) Percentages with respect to the 450K (n = 482,287). (B) Percentages are displayed with respect to the number of significant age-related DMCs (n = 14,622). (C–E) By DNA methylation subgroup (Abbreviations: UM: unmethylated, mean β-value <0.2; HM: hemi-methylated, 0.20 ≤ mean β-value ≤0.80; FM: fully methylated, mean β-value >0.80).