Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

Eugenia Casella; Jana Depovere; Chantal Delger; Mariia Butynets; Philipp Antczak; Thomas Price; Randy L. Jirtle; Susan K. Murphy; Cathrine Hoyo; Adelheid Soubry

doi:doi:10.18632/aging.206348

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Research Paper Volume 17, Issue 12 pp 2950—2988

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

Figure 9. DNA methylation by age at CpGs linked to imprinted genes and related to ASD. Estimates of DNA methylation in β-values by age of CpG sites mapped to our selected list of ASD-related imprinted genes (with exception of CpGs mapped to DLGAP2, which are shown in Figure 8). Fitted regression lines are shown. Our regression models included potential confounding factors (BMI and patient status), and we corrected for multiple testing (BH-method). (A–E) maternally expressed genes; (F–J) paternally expressed genes; (K, L) isoform dependent transcribed gene. If more than one CpG site per gene was significant, the one with the lowest p-value is shown.