Research Paper Volume 18 pp 5—29

Transcript length is associated with cellular aging and predicts accelerated aging in specific T cell subsets. (A–F) Mean transcript length per cell type and age group for naïve CD8, memory CD8, effector CD8, naïve CD4, memory CD4, and regulatory T cells. Shorter transcript lengths are associated with increased age for most subsets, except naïve CD4 and memory CD8 T cells. (G–L) Transcript length comparisons in cells from the top and bottom 10% deciles of predicted age acceleration relative to chronological age. Longer mean transcript lengths are associated with younger predicted ages in regulatory T cells and memory CD4 cells. Statistical significance is indicated: ^*** Bonferroni-corrected p-value less than or equal to .001, ^* Bonferroni-corrected P-value less than or equal to .05, ^# Bonferroni-corrected P-value less than or equal to .1.