Research Perspective Volume 18 pp 59—66
A decline in glycolytic ATP production is the fundamental mechanism limiting lifespan; species with an optimal rate of decline over time survived
Schematic representation of the simple concept linking aging and glycolytic ATP production. Decline in glycolytic ATP production over time has both disadvantages and advantages. Various questions about aging can be explained by the concept that species that happened to have an optimal rate of decline were selected and survived through generational changes.