Research Paper Volume 18 pp 82—99
D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice
Unlike the SAAR diet, BSO does not decrease cortical bone mineral density. Images of cortical cross-sections are shown in (A). Similar to its effect on the trabecular bone, the SAAR diet (B) decreased cortical thickness (SAAR < CD) and (C) increased periosteal radius (SAAR > CD), indicating a decrease in cortical bone density. However, the SAAR diet did not affect (D) endosteal radius (SAAR = CD) and (E) bone tissue density (SAAR = CD). NAC, as expected, reversed the decrease in cortical thickness (SAAR < [CD = NAC] in figure B) but did not affect other measures. BSO did not exert any effects at all (CD = BSO). Note: Sample sizes and statistical methods are similar to those in