Research Paper Volume 18 pp 82—99
D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice
Mice on the BSO had bones with similar mechanical strength to those on the control diet. The SAAR diet decreased (A) stiffness (SAAR < CD) and (B) maximum load (SAAR < CD), while NAC reversed both effects (SAAR < [CD = NAC]). Neither the SAAR diet nor NAC affected (C) total work (SAAR = CD = NAC) and (D) post-yield deflection (SAAR = CD = NAC). BSO did not affect any measure of mechanical strength at all (CD = BSO). Note: Sample sizes and statistical methods are similar to those in