Research Paper Volume 18 pp 82—99
D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice
The SAAR diet, but not BSO, increases marrow adipocytes in tibiae. Micro-CT (first row) and photomicrographs (second row) of osmium-stained images of tibiae are shown in (A). Compared with the CD, the SAAR diet increased marrow adipocytes at volumes of interest 2 and 4, but not at volume of interest 3 (B–D, SAAR > CD). NAC reversed the increase in SAAR at all volumes of interest (B–D, SAAR > [CD = NAC]), while BSO had no effect (CD = BSO). Sample sizes and statistical methods are similar to those in