Research Paper Volume 18 pp 234—260
A manually curated gene–phenotype catalogue for progeroid syndromes and premature aging
Protein–protein interaction (PPI) network of proteins encoded by genes associated with progeroid syndromes. The network was visualized using the STRING tool and includes only known interactions: blue edges represent interactions from curated databases, while pink edges indicate experimentally determined interactions. The network comprises 142 nodes and 720 edges, with an average node degree of 10.1 and an average local clustering coefficient of 0.618. The PPI enrichment p-value is <1.0 × 10−¹6.