Research Paper Volume 18 pp 303—326
Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer’s disease neurodegeneration
Associations of DNAm SmokingPackYears from AgeAccelGrim2 with global and regional brain volumes (in cm3) from linear regression models adjusting for chronological age, hormone therapy trial arm, education, smoking status, race, ethnicity, physical activity, BMI, diabetes, cardiovascular disease, cancer, blood cell composition, and intracranial volume. Beta coefficients are reported for each 1 standard deviation increase in the epigenetic measure.