Figure 2.Tissue-specific triggers of aging. The illustration demonstrates the primary senescence-inducing factors across diverse tissues, which exhibit both commonalities and tissue-specific heterogeneity. These stressors eventually activate key aging-related pathways, such as the p16/Rb axis, leading to cellular senescence. Furthermore, various tissues interact by secreting factors like SASP into the blood circulation, thereby influencing distant organs and driving a systemic aging process.
