Figure 2 — Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled trial

Research Paper|Volume 18|pp. 639–655

Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled trial

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Figure 2.Effect of the multimodal lifestyle intervention on DNA methylation-based clocks. Data are presented as adjusted mean changes from baseline with 95% confidence intervals (CI). Open and black circles represent an adjusted mean change in the CON and INT group, respectively. Scale bars show 95% CI. The dotted line indicates zero. Asterisks (*) indicate significant between-group differences by ANCOVA (p < 0.05). Panels show; (A) DunedinPACE; (B) GrimAge; (C) GrimAge v2; (D) PC-Horvath clock; (E) PC-Hannum clock; (F) PC-PhenoAge.