Aging | Lamin A to Z in Normal Aging
11-09-2022“It has long been debated to what extent the mechanisms of aging and progeria overlap.”
BUFFALO, NY- November 9, 2022 – A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 20, entitled, “Lamin A to Z in normal aging.”
Almost since the discovery that mutations in the LMNA gene, encoding the nuclear structure components lamin A and C, lead to Hutchinson-Gilford progeria syndrome (HGPS), people have speculated that lamins may have a role in normal aging.
The most common HPGS mutation creates a splice variant of lamin A, progerin, which promotes accelerated aging pathology. While some evidence exists that progerin accumulates with normal aging, an increasing body of work indicates that prelamin A, a precursor of lamin A prior to C-terminal proteolytic processing, accumulates with age and may be a driver of normal aging. Prelamin A shares properties with progerin and is also linked to a rare progeroid disease, restrictive dermopathy.
“Patients with the laminopathy, restrictive dermopathy (RD), have mutations in either ZMPSTE24 or LMNA, the latter associated with altered processing and the accumulation of prelamin A [4, 29]. RD has some phenotypes of accelerated aging; however, the condition is often very early onset and severe, making comparison with normal aging more challenging.”
In this new research perspective, researchers Stanley R. Primmer, Chen-Yu Liao, Oona M.P. Kummert, and Brian K. Kennedy from the Buck Institute for Research on Aging, National University of Singapore and National University Health System describe mechanisms underlying changes in prelamin A with aging and lay out the case that this unprocessed protein impacts normative aging.
“This is important since intervention strategies can be developed to modify this pathway as a means to extend healthspan and lifespan.”
DOI: https://doi.org/10.18632/aging.204342
Corresponding Author: Brian K. Kennedy - bkennedy@nus.edu.sg
Keywords: lamin A, prelamin A, zmpste24, mTOR, aging
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About Aging-US:
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
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