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2023 Press Releases
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Aging Modulates Extracellular Vesicles of Epidermal Keratinocytes
11-30-2023“In this article, we describe for the first time the impact of chronological aging on EVs production by human keratinocytes."
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BUFFALO, NY- November 30, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …
Anti-Aging Effects of 1,5-Anhydro-D-Fructose on Brain Diseases via AMPK Activation
11-28-2023“Our results suggest that 1,5-AF has preventive effects on aging-associated brain diseases via the AMPK/PGC-1α/BDNF pathway [...]”
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BUFFALO, NY- November 28, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" …
Mitochondria-Targeting Antibiotics Extend Lifespan in C. Elegans
11-22-2023“Our ultimate goal is to find existing FDA-approved drugs and dietary supplements that can not only increase lifespan but also improve healthspan.”
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BUFFALO, NY- November 22, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany …
Parental Age Effect on the Longevity and Healthspan of Flies and Worms
11-21-2023“[...] little work [has been] published on the effect of parental age in the nematode Caenorhabditis elegans, a common model organism for aging studies.”
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BUFFALO, NY- November 21, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …
Behavioral, Morphological and Transcriptomic Changes in a Tauopathy Mouse Model
11-15-2023“Here we used the PS19 (P301S) mouse model of tauopathies to characterize longitudinal changes in behavioral, morphological, and transcriptomic levels.”
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BUFFALO, NY- November 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …
Alcohol Consumption and Epigenetic Age Acceleration Across Adulthood
11-14-2023“Our findings may help to understand the role of alcohol-associated biological aging in the development of age-related diseases such as CVD and cancer.”
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BUFFALO, NY- November 14, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …
A New Connection Between The Gut Microbiota and Prostate Inflammation in Aging Men
11-08-2023“Creating a properly functioning intestinal microenvironment can significantly reduce the overall inflammation, which also affects the prostate.”
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BUFFALO, NY- November 8, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …
Deciphering Reproductive Aging in Women Using a NOD/SCID Mouse Model
11-07-2023“The proposed NOD/SCID model, with its accelerated ovarian aging, holds particular value as it will enable the observation of ovarian changes within a shorter timeframe.”
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BUFFALO, NY- November 7, 2023 – A new research paper was published in Aging (listed by …
Parkinson Disease and Normal Aging
11-01-2023“Our principal component analyses showed a significant relationship between centro-cingulate cholinergic afferent changes and age in our Parkinson disease subjects.”
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BUFFALO, NY- November 1, 2023 – A new research perspective was published in Aging (listed by …
Aging-Related Fibro-Inflammatory Signature in Mouse Ovaries
10-31-2023“Overall, our study provides novel insight into how reproductive aging impacts the murine ovarian proteome and ECM.”
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BUFFALO, NY- October 31, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …
Autophagy’s Role in DNA Loss and Survival of Diploid Yeast Cells During Chronological Aging
10-25-2023“In other words, cells live as long as their genome is restorable, and full DNA content is the limit of life.”
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BUFFALO, NY- October 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) V…
Integrative Analysis Reveals Metabolic Switch in Aging Astrocytes
10-24-2023“We identified candidates for preclinical studies targeting energy metabolism to prevent age-associated cognitive decline.”
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BUFFALO, NY- October 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web …
Reducing Double-strand DNA Break Repair Exacerbates Vascular Aging
10-18-2023“[...] this suggests a model where the accumulation of DNA damage with aging impairs vascular function ultimately resulting in [cardiovascular disease].”
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BUFFALO, NY- October 18, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …
Senescence Program Modulated by BMAL1 via AP-1
10-16-2023“In this study, we discovered that senescence alters the amplitude and period of core circadian clock components, most notably BMAL1 [...]”
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BUFFALO, NY- October 16, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging …
Insights on Disparities in Dementia From the UK Biobank Study
10-11-2023“The present study is among few to examine racial/ethnic disparities in dementia risk and their related pathways [...]. It is the first to do so in a UK population.”
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BUFFALO, NY- October 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as …
B Cell Response After Influenza Vaccine in Young and Older Adults
10-10-2023“[...] our findings suggest that the age-related decrease in response following influenza vaccination could reflect functional alterations in activated B cells [...]”
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BUFFALO, NY- October 10, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed …
AI Model for Age-Related Disease Target Discovery
10-04-2023“In this work, we focused on the application of the established pipeline to the identification of the potential targets related to aging [...]”
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BUFFALO, NY- October 4, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …
Genetic Profiles of Senescent Corneal and Conjunctival Epithelial Cells in Humans
10-02-2023“[...] our results from the RNA-Seq experiments show that senescent ocular surface cells, particularly SCj, have abnormal keratin expression patterns [...]”
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BUFFALO, NY- October 2, 2023 – A new priority research paper was published on the cover of Aging (listed by …
Opportunities to Improve Lung Cancer Care for Older Patients
09-27-2023“With the majority of lung cancer patients being older than 65, it is imperative that actions are taken to encourage and facilitate clinical trials among older patients.”
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BUFFALO, NY- September 27, 2023 – A new editorial paper was published in Aging (listed by …
Living Donor Liver Transplant Access is Optimal for High-risk Waitlisted Cirrhosis Patients
09-26-2023“Access to LDLT in a transplant program can optimize the timing of transplant for the increasingly older, frail patient population [...]”
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BUFFALO, NY- September 26, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …
DNA Damage-induced Senescence Model in Osteoarthritic Chondrocytes
09-20-2023“This etoposide-induced senescence model may help investigate the initiation of cellular senescence in chondrocytes [...]”
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BUFFALO, NY- September 20, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web …
Development of a Noise Barometer for Measuring Epigenetic Pressure of Aging and Disease
09-18-2023“[...] we describe a conceptually different measurement (not a prediction) of persons’ biological age, which we term a noise barometer [...]”
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BUFFALO, NY- September 18, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …
Contributions to White Matter Injury in Alzheimer’s Disease
09-12-2023“The molecular mechanisms that mediate enhanced dysfunction of white matter parenchymal arterioles when vascular dysfunction and ADNC coincide remain elusive.”
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BUFFALO, NY- September 12, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as …
Copy Number Variation Implements Pregnancy as an Aging Model
09-06-2023“Such knowledge on physiological decline throughout pregnancy and the remarkable rejuvenation right after delivery will assist with revolutionizing our approach to treating the elderly.”
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BUFFALO, NY- September 6, 2023 – A new research paper was published in Aging (listed …
Aging Alters Pancreatic Circadian Rhythm
09-05-2023“Overall, our study identified previously unknown circadian transcriptome reorganization of pancreas by aging [...]”
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BUFFALO, NY- September 5, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
Dectin-1 Stimulation Promotes Distinct Inflammatory Signature in HIV and Aging
08-31-2023“To our knowledge, our study is the first to evaluate the specific function of Dectin-1 in the setting of aging and HIV-infection.”
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BUFFALO, NY- August 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …
Editorial: Epigenetic Aging in Oocytes
08-30-2023“In summary, our group demonstrates basic principles in the early aging of mammalian oocytes.”
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BUFFALO, NY- August 30, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue …
Catheter Ablation in Very Old Patients With Nonvalvular Atrial Fibrillation
08-22-2023“To the best of our knowledge, this is the first study to have demonstrated the preventive effect of AF ablation on long-term AF-related cardiovascular events in very old patients with NVAF.”
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BUFFALO, NY- August 22, 2023 – A new research paper was published in Aging …
Exploring the Relationship Between Klotho and Telomere Biology in High-Stress Caregivers
08-17-2023“As expected, mothers caring for a child with ASD reported significantly higher perceived stress [...] than mothers caring for a neurotypical child...”
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BUFFALO, NY- August 17, 2023 – A new research paper was published by Aging (listed by MEDLINE/PubMed as "Aging (Albany …
Aging and Ovariectomy Induces Parallel Phosphoproteomic Changes in Skeletal Muscle of Female Mice
08-15-2023“Our findings highlight key molecular signatures and pathways in contracted muscle [...] that may contribute to skeletal muscle strength loss due to estrogen deficiency.”
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BUFFALO, NY- August 15, 2023 – A new research paper was published on the cover of Aging (listed by …
A Novel Theory of Aging — Independent of Damage Accumulation
08-09-2023“We argue that in multicellular organisms, neighbouring cells are in constant competition.”
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BUFFALO, NY- August 9, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, …
Inhibiting NLRP3 Signaling in Aging Podocytes Improves Longevity
08-08-2023“Together, these results suggest a critical role for the NLRP3 inflammasome in podocyte and liver aging.”
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BUFFALO, NY- August 8, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume …
Towards Disease-Oriented Dosing of Rapamycin for Longevity
08-02-2023"To understand a sum of quasi-programs (aging), we need to study early-life hyperfunctions."
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BUFFALO, NY- August 2, 2023 – A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, …
Human Senescent Fibroblasts Cause Lung Fibrosis in Mice
07-31-2023“These observations support that accumulation of senescent cells may contribute to fibrotic lung disease [...]”
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BUFFALO, NY- July 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
Predicting Lifespan-Extending Chemical Compounds for C. Elegans With Machine Learning
07-26-2023“We created datasets for predicting whether or not a compound extends the lifespan of C. elegans [...]”
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BUFFALO, NY- July 26, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, …
MSK1’s Required Role in Cognitive Benefits from Enriched Experiences in Old Age
07-25-2023“We show that MSK1 retains its importance in converting positive experience into tangible synaptic and cognitive benefits well into old age [...]”
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BUFFALO, NY- July 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …
Cognitive Rescue in Aging Through Prior Training
07-19-2023“Prior training shows profound benefits in cognitive aging [...]”
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BUFFALO, NY- July 19, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, “Cognitive rescue …
BUB1 Regulates EGFR Signaling by Reducing EGFR Internalization
07-17-2023“We postulate that these observations may provide novel opportunities for therapeutic interventions for EGFR driven cancers.”
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BUFFALO, NY- July 17, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web …
The Memtrax Continuous Recognition Test for Advanced Cognitive Impairment Screening
07-13-2023“[...] MemTrax quickly demonstrates and quantifies the pertinent memory dysfunction of Alzheimer’s disease.”
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BUFFALO, NY- July 13, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume…
NEW STUDY: Discovery of Chemical Means to Reverse Aging and Restore Cellular Function
07-12-2023On July 12, 2023, a new priority research paper was published in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”
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BUFFALO, NY- July 12, 2023 – In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and …
Hepatic Hydrogen Sulfide Levels are Reduced in Mouse Model of Progeria
07-11-2023“To date, no studies have directly measured [hydrogen sulfide] production in Hutchinson-Gilford Progeria Syndrome [...]”
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BUFFALO, NY- July 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
A Novel Peptide ‘T14’ Reflects Age and Photo-Aging in Human Skin
07-05-2023“[...] the results suggest a possible novel approach [for] exploring skin disorders [...]”
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BUFFALO, NY- July 5, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, …
Age Prediction From Human Blood Plasma Using Proteomic and Small RNA Data: A Comparative Analysis
06-30-2023“[...] we see our work as an indication that combining different molecular data types could be a general strategy to improve future aging clocks.”
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BUFFALO, NY- June 30, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging …
Senescence and Senotherapies in Biliary Atresia and Biliary Cirrhosis
06-28-2023“Our data provide the first integrative report about premature senescence in pediatric [biliary atresia] [...]”
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BUFFALO, NY- June 28, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volu…
Methionine Restriction Reverses Old-age Obesity in Mice
06-27-2023“This is the first report that showed the efficacy of methionine restriction to reverse old-age-induced obesity.”
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BUFFALO, NY- June 27, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Vo…
Precious1GPT: Multimodal Transfer Learning for Aging Clock Development and Target Discovery
06-20-2023“The development of Precious1GPT [...] has demonstrated the potential of our approach in deciphering the molecular mechanisms of aging.”
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BUFFALO, NY- June 20, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …
Aging Sponsors 2023 Ride for Roswell
06-19-2023Aging's publisher, Impact Journals, is sponsoring Team Open Access in the annual cycling event to end cancer: The Ride for Roswell. This fundraiser is hosted by Roswell Park Comprehensive Cancer Center in Buffalo, New York.
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BUFFALO, NY- June 19, 2023 – The Ride for …
Short Telomeres in Alveolar Type II Cells Associate With Lung Fibrosis in Post COVID-19 Patients With Cancer
06-15-2023“[...] here we reveal a link between short telomere length in ATII cells and post-viral lung fibrosis outcome in post-COVID-19 patients.”
BUFFALO, NY- June 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, …
Cellular Senescence Involves Gene Repression Through p53-p16/RB-E2F-DREAM Complex
06-13-2023“Our study enables us to envisage a global picture of genes and pathways dysregulated during senescence and provides novel evidence for involvement of p53/p16/RB-E2F-DREAM repressional targets in this complex cellular process.”
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BUFFALO, NY- June 13, 2023 – A new research …
DNAmFitAge: Biological Age Indicator Incorporating Physical Fitness
06-07-2023“We expect DNAmFitAge will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions.”
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BUFFALO, NY- June 7, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …
Stress Granules Control Alzheimer's Gene Transcripts and Neuronal Proteostasis
06-01-2023“Determining the mechanism underlying RNA sequestration in [stress granules] [...] could represent a key goal in the discovery and development of suitable [Alzheimer’s disease] biomarkers and therapies.”
BUFFALO, NY- June 1, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …
External Factors Shape Genetic Predisposition to Lipids, Alzheimer’s and Heart Disease in MLXIPL Gene
05-24-2023“Recent findings suggest that neurodegenerative and cardiovascular diseases may have overlapping etiologies [...]”
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BUFFALO, NY- May 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Vo…
The Aging Mouse Prostate: Kinetics of Lymphocyte Infiltration
05-23-2023“This dataset presents the most comprehensive profiling of the aging adult mouse prostate immune profile to date.”
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BUFFALO, NY- May 23, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Vo…
Aging (Aging-US) at SSP 45th Annual Meeting
05-17-2023Impact Journals (Aging's publisher) is proud to participate at the Society for Scholarly Publishing (SSP) 45th Annual Meeting, which convenes May 31–June 2, 2023, in Portland, Oregon.
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BUFFALO, NY-May 17, 2023 – Impact Journals (Aging's publisher) will be participating as …
Musashi 1 in Breast Cancer: Implications for Dormancy and Survival in Bone Marrow
05-16-2023“This study now links Msi 1 to PD-L1.”
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BUFFALO, NY- May 16, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Increased expression of musashi 1 on breast …
Effects of Zoledronic Acid on Senescence and SASP Markers
05-15-2023“In the present study, we used multiple complementary approaches to evaluate the possible effects of zoledronic acid on cellular senescence.”
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BUFFALO, NY- May 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany …
The Senescence-Associated Secretory Phenotype Induces Neuroendocrine Transdifferentiation
05-12-2023“We recently unveiled a new interesting role for SASP: its ability to induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells [3].”
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BUFFALO, NY- May 12, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging …
An Epigenetic Approach to Modulating Aging With Nutrition and Exercise
05-10-2023“In this review, we describe how aging impacts epigenetics and how nutrition and physical exercise can positively impact the aging process, from an epigenetic point of view.”
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BUFFALO, NY- May 10, 2023 – A new review paper was published in Aging (listed by MEDLINE/PubMed …
Single-Cell Transcriptomic Analysis Uncovers Diverse and Dynamic Senescent Cell Populations
05-09-2023“In summary, single-cell transcriptomic analysis has allowed us to identify the specific populations and the dynamic transition states during senescence initiation and progression.”
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BUFFALO, NY- May 9, 2023 – A new research paper was published in Aging (listed by …
Dual-Purpose Therapeutic Targets for Aging and Glioblastoma Identified with PandaOmics
05-02-2023“[...] AI-powered algorithms, such as PandaOmics, may accelerate subsequent gene target discovery not only for GBM but for a broader range of age-associated diseases.”
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BUFFALO, NY- May 2, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as …
A Chronic Wound Model to Investigate Skin Cellular Senescence
05-01-2023“Here, we report a chronic wound healing model that can be used to decipher the paradoxical role of cellular senescence in acute versus chronic wound healing.”
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BUFFALO, NY- May 1, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed …
Effect of Deferoxamine and Ferrostatin-1 on Salivary Gland Dysfunction in Ovariectomized Rats
04-26-2023“[...] this study is expected to be helpful in [...] developing a treatment for postmenopausal dry mouth.”
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BUFFALO, NY- April 26, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume …
Characterization of the HDAC/PI3K Inhibitor CUDC-907 as a Novel Senolytic
04-25-2023“The mechanisms of induction of senescent cell death by CUDC-907 remain to be fully elucidated.”
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BUFFALO, NY- April 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 7…
Serine Racemase Upregulation Improves Learning and Synaptic Function
04-19-2023“The results from this study support the beneficial effects of the D-serine pathway involvement in NMDAR-mediated transmission and cognitive function [...]”
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BUFFALO, NY- April 19, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …
p21 Facilitates Chronic Lung Inflammation via Epithelial and Endothelial Cells
04-17-2023“Our results implicate p21 as a critical regulator of chronic bronchitis and a driver of chronic airway inflammation and lung destruction.”
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BUFFALO, NY- April 17, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany …
Selenium as a Predictor of Metabolic Syndrome in Middle Age Women
04-12-2023“Recently, optimizing selenium intake in the population to prevent diseases [...] has been an important issue in modern health care worldwide.”
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BUFFALO, NY- April 12, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …
Knockout of AMD-Associated Gene POLDIP2 Reduces Mitochondrial Superoxide in Retinal Cells
04-11-2023“To our knowledge, this is the first functional study of POLDIP2 in retinal cells to understand its potential role in AMD.”
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BUFFALO, NY- April 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
Aging at AACR Annual Meeting 2023
04-04-2023Impact Journals (Aging's publisher) is proud to participate at the American Association for Cancer Research (AACR) Annual Meeting 2023, which convenes April 14-19 in Orlando, Florida.
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BUFFALO, NY-April 4, 2023 – Impact Journals will be participating as an exhibitor at …
Diet/Lifestyle Program Reverses Biological Age: A Female Case Series
04-03-2023“[...] these data suggest that a methylation-supportive diet and lifestyle intervention may favorably influence biological age in both sexes during middle age and older.”
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BUFFALO, NY- April 3, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed …
Metformin & Leucine Prevent Cellular Senescence & Proteostasis Disruption
03-31-2023“Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.”
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BUFFALO, NY- March 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …
Senescence and Extracellular Vesicles: Novel Partners in Vascular Amyloidosis
03-29-2023“[...] there has been limited research to date on the effect of cellular ‘ageing’, termed senescence, on amyloidosis.”
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BUFFALO, NY- March 29, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
Parsing Chronological and Biological Age Effects on Vaccine Responses
03-27-2023“Ultimately, while both chronological and biological age appear to be important determinants of vaccine-preventable outcomes in older adults, the underlying context and mechanisms of their effects remain unclear.”
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BUFFALO, NY- March 27, 2023 – A new editorial paper was …
Age-Related Methylation Changes in the Human Sperm Epigenome
03-21-2023“[...] we identified > 1,000 candidate genes with genome-wide significant age-related methylation changes in sperm.”
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BUFFALO, NY- March 21, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
Senescence-Associated Exosomes Transfer Fibrosis to Neighboring Cells
03-17-2023“This shows that SA-EXOs can serve as potent SASP mediators that activate invasive characteristics in neighboring cells.”
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BUFFALO, NY- March 17, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …
AAV1.NT-3 Gene Therapy Prevents Age-Related Sarcopenia
03-15-2023“Considering the cost and quality of life to the individual, we believe our study has important implications for management of age-related sarcopenia.”
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BUFFALO, NY- March 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …
Cognitive Aging and Dementia Prevention: The Time for Psychology?
03-10-2023“[...] there is a need to explore brain mechanisms through which psychological processes may exert their protective or deleterious effects.”
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BUFFALO, NY- March 10, 2023 – Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) published a …
Isoform-Specific AMPK Repression Affects Cognitive Function in Aged Mice
03-07-2023“The study indicates that the aging process might have distinct impact on the signaling pathways associated with the AMPKα isoforms [...]”
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BUFFALO, NY- March 7, 2023 – Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) published a …
Cellular Senescence: When Growth Stimulation Meets Cell Cycle Arrest
03-02-2023“Growth and aging are driven by overlapping signaling pathways.”
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BUFFALO, NY- March 2, 2023 – Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) published a new review paper in Volume 15, Issue 4, entitled, “Cellular senescence: when …
Telomere Shortening Linked to Depression and Cognitive Impairment in Older Adults
02-28-2023“[...] we believe that our findings will help prevent and treat depression and cognitive impairment in the healthy elderly.”
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BUFFALO, NY- February 28, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and …
Metformin's Impact on Aging and Longevity Through DNA Methylation
02-22-2023“In this study, we compared genome-wide DNA methylation rates among metformin users and nonusers [...]”
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BUFFALO, NY- February 22, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume …
Epigenetic Age and Lung Cancer Risk in the CLUE II Prospective Cohort Study
02-16-2023“In this nested case-control study on incident lung cancer, we observed no positive associations between lung cancer risk and epigenetic age acceleration [...]”
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BUFFALO, NY- February 16, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by …
Immune-Mediated Platelet Depletion Augments Alzheimer’s Disease in Mice
02-15-2023“Our study suggests that platelets might contribute to limiting amyloid plaque size and neuronal damage, having a beneficial role in AD [Alzheimer’s disease].”
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BUFFALO, NY- February 15, 2023 – A new research paper was published on the cover of Aging (listed as "Aging …
Body Weight Influences Musculoskeletal Adaptation to Running in Aging Mice
02-08-2023“[...] [voluntary wheel running] differentially alters bone parameters depending on body weight [...]”
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BUFFALO, NY- February 8, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume …
Are Menopause, Aging and Prostate Cancer Diseases?
02-02-2023“Aging can be understood through the development of all quasi-programmed diseases.”
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BUFFALO, NY- February 2, 2023 – A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, …
Clearance of p16Ink4a+ Cells: Limited Effects on β-Cell Mass and Proliferation in Mice
01-31-2023“[...] we set out to explore the effects of removing p16Ink4a+ senescent cells on the proliferative capacity and mass of β-cells [...].”
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BUFFALO, NY- January 31, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by …
The Innate Immune Signaling Component FBXC-58 Mediates Dietary Restriction Effects on Healthy Aging in Caenorhabditis elegans
01-25-2023“In this study, we found that DR prevents muscle aging via fbxc-58 in C. elegans.”
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BUFFALO, NY- January 25, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 1, entitled, …
Genetic Deficiency and Pharmacological Modulation of RORα Regulate Laser-Induced Choroidal Neovascularization
01-18-2023“In this study, we present findings for a protective role of RORα in a mouse laser-induced CNV model of neovascular AMD.”
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BUFFALO, NY- January 18, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of …
Single-Cell Transcriptomics of Peripheral Blood in the Aging Mouse
01-16-2023“Here, we profiled 14588 single cells from the mouse blood and assessed the differences between young and old mice.”
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BUFFALO, NY- January 16, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" …
Transcriptomic Analysis of Human ALS Skeletal Muscle Reveals Disease-Specific Pattern of Dysregulated circRNAs
01-12-2023“In this work, we have identified distinct patterns of circRNA expression in human ALS muscle tissue, many appearing to be disease-specific, that display expression gradients at different levels within the CNS.”
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BUFFALO, NY- January 12, 2023 – A new research paper was …
Epigenetic Aging Associated With Aberrant Neural Oscillatory Dynamics Serving Visuospatial Processing in People With HIV
01-05-2023“Thus, these findings are the first to identify the interaction between biological age and HIV status on neural oscillatory dynamics serving cognitive function, and more specifically, visuospatial processing.”
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BUFFALO, NY- January 5, 2023 – A new research paper was …
Associations of APOE ε2 and ε4 Alleles and Polygenic Profiles Comprising APOE-TOMM40-APOC1 Variants With Alzheimer’s Disease Biomarkers
01-03-2023“The thickness of the arrows denotes tighter (thick lines) and weaker (thin lines) links between genetic variants, AD biomarkers, and cognitive impairment.”
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BUFFALO, NY- January 3, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany …