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2023 Press Releases

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Aging Modulates Extracellular Vesicles of Epidermal Keratinocytes

11-30-2023

“In this article, we describe for the first time the impact of chronological aging on EVs production by human keratinocytes."

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BUFFALO, NY- November 30, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …

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Anti-Aging Effects of 1,5-Anhydro-D-Fructose on Brain Diseases via AMPK Activation

11-28-2023

“Our results suggest that 1,5-AF has preventive effects on aging-associated brain diseases via the AMPK/PGC-1α/BDNF pathway [...]”

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BUFFALO, NY- November 28, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" …

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Mitochondria-Targeting Antibiotics Extend Lifespan in C. Elegans

11-22-2023

“Our ultimate goal is to find existing FDA-approved drugs and dietary supplements that can not only increase lifespan but also improve healthspan.” 

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BUFFALO, NY- November 22, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany …

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Parental Age Effect on the Longevity and Healthspan of Flies and Worms

11-21-2023

“[...] little work [has been] published on the effect of parental age in the nematode Caenorhabditis elegans, a common model organism for aging studies.”

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BUFFALO, NY- November 21, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …

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Behavioral, Morphological and Transcriptomic Changes in a Tauopathy Mouse Model

11-15-2023

“Here we used the PS19 (P301S) mouse model of tauopathies to characterize longitudinal changes in behavioral, morphological, and transcriptomic levels.”

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BUFFALO, NY- November 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …

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Alcohol Consumption and Epigenetic Age Acceleration Across Adulthood

11-14-2023

“Our findings may help to understand the role of alcohol-associated biological aging in the development of age-related diseases such as CVD and cancer.” 

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BUFFALO, NY- November 14, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …

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A New Connection Between The Gut Microbiota and Prostate Inflammation in Aging Men

11-08-2023

“Creating a properly functioning intestinal microenvironment can significantly reduce the overall inflammation, which also affects the prostate.” 

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BUFFALO, NY- November 8, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …

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Deciphering Reproductive Aging in Women Using a NOD/SCID Mouse Model

11-07-2023

“The proposed NOD/SCID model, with its accelerated ovarian aging, holds particular value as it will enable the observation of ovarian changes within a shorter timeframe.” 

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BUFFALO, NY- November 7, 2023 – A new research paper was published in Aging (listed by …

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Parkinson Disease and Normal Aging

11-01-2023

“Our principal component analyses showed a significant relationship between centro-cingulate cholinergic afferent changes and age in our Parkinson disease subjects.”

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BUFFALO, NY- November 1, 2023 – A new research perspective was published in Aging (listed by …

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Aging-Related Fibro-Inflammatory Signature in Mouse Ovaries

10-31-2023

“Overall, our study provides novel insight into how reproductive aging impacts the murine ovarian proteome and ECM.”

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BUFFALO, NY- October 31, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …

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Autophagy’s Role in DNA Loss and Survival of Diploid Yeast Cells During Chronological Aging

10-25-2023

“In other words, cells live as long as their genome is restorable, and full DNA content is the limit of life.” 

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BUFFALO, NY- October 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) V…

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Integrative Analysis Reveals Metabolic Switch in Aging Astrocytes

10-24-2023

“We identified candidates for preclinical studies targeting energy metabolism to prevent age-associated cognitive decline.”

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BUFFALO, NY- October 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web …

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Reducing Double-strand DNA Break Repair Exacerbates Vascular Aging

10-18-2023

“[...] this suggests a model where the accumulation of DNA damage with aging impairs vascular function ultimately resulting in [cardiovascular disease].”

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BUFFALO, NY- October 18, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …

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Senescence Program Modulated by BMAL1 via AP-1

10-16-2023

“In this study, we discovered that senescence alters the amplitude and period of core circadian clock components, most notably BMAL1 [...]”

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BUFFALO, NY- October 16, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging …

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Insights on Disparities in Dementia From the UK Biobank Study

10-11-2023

“The present study is among few to examine racial/ethnic disparities in dementia risk and their related pathways [...]. It is the first to do so in a UK population.” 

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BUFFALO, NY- October 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as …

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B Cell Response After Influenza Vaccine in Young and Older Adults

10-10-2023

“[...] our findings suggest that the age-related decrease in response following influenza vaccination could reflect functional alterations in activated B cells [...]” 

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BUFFALO, NY- October 10, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed …

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AI Model for Age-Related Disease Target Discovery

10-04-2023

“In this work, we focused on the application of the established pipeline to the identification of the potential targets related to aging [...]” 

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BUFFALO, NY- October 4, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …

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Genetic Profiles of Senescent Corneal and Conjunctival Epithelial Cells in Humans

10-02-2023

“[...] our results from the RNA-Seq experiments show that senescent ocular surface cells, particularly SCj, have abnormal keratin expression patterns [...]”

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BUFFALO, NY- October 2, 2023 – A new priority research paper was published on the cover of Aging (listed by …

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Opportunities to Improve Lung Cancer Care for Older Patients

09-27-2023

“With the majority of lung cancer patients being older than 65, it is imperative that actions are taken to encourage and facilitate clinical trials among older patients.” 

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BUFFALO, NY- September 27, 2023 – A new editorial paper was published in Aging (listed by …

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Living Donor Liver Transplant Access is Optimal for High-risk Waitlisted Cirrhosis Patients

09-26-2023

“Access to LDLT in a transplant program can optimize the timing of transplant for the increasingly older, frail patient population [...]” 

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BUFFALO, NY- September 26, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …

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DNA Damage-induced Senescence Model in Osteoarthritic Chondrocytes

09-20-2023

“This etoposide-induced senescence model may help investigate the initiation of cellular senescence in chondrocytes [...]”

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BUFFALO, NY- September 20, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web …

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Development of a Noise Barometer for Measuring Epigenetic Pressure of Aging and Disease

09-18-2023

“[...] we describe a conceptually different measurement (not a prediction) of persons’ biological age, which we term a noise barometer [...]”

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BUFFALO, NY- September 18, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …

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Contributions to White Matter Injury in Alzheimer’s Disease

09-12-2023

“The molecular mechanisms that mediate enhanced dysfunction of white matter parenchymal arterioles when vascular dysfunction and ADNC coincide remain elusive.”

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BUFFALO, NY- September 12, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as …

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Copy Number Variation Implements Pregnancy as an Aging Model

09-06-2023

“Such knowledge on physiological decline throughout pregnancy and the remarkable rejuvenation right after delivery will assist with revolutionizing our approach to treating the elderly.”

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BUFFALO, NY- September 6, 2023 – A new research paper was published in Aging (listed …

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Aging Alters Pancreatic Circadian Rhythm

09-05-2023

“Overall, our study identified previously unknown circadian transcriptome reorganization of pancreas by aging [...]”

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BUFFALO, NY- September 5, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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Dectin-1 Stimulation Promotes Distinct Inflammatory Signature in HIV and Aging

08-31-2023

“To our knowledge, our study is the first to evaluate the specific function of Dectin-1 in the setting of aging and HIV-infection.”

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BUFFALO, NY- August 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …

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Editorial: Epigenetic Aging in Oocytes

08-30-2023

“In summary, our group demonstrates basic principles in the early aging of mammalian oocytes.” 

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BUFFALO, NY- August 30, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue …

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Catheter Ablation in Very Old Patients With Nonvalvular Atrial Fibrillation

08-22-2023

“To the best of our knowledge, this is the first study to have demonstrated the preventive effect of AF ablation on long-term AF-related cardiovascular events in very old patients with NVAF.” 

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BUFFALO, NY- August 22, 2023 – A new research paper was published in Aging

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Exploring the Relationship Between Klotho and Telomere Biology in High-Stress Caregivers

08-17-2023

“As expected, mothers caring for a child with ASD reported significantly higher perceived stress [...] than mothers caring for a neurotypical child...”

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BUFFALO, NY- August 17, 2023 – A new research paper was published by Aging (listed by MEDLINE/PubMed as "Aging (Albany …

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Aging and Ovariectomy Induces Parallel Phosphoproteomic Changes in Skeletal Muscle of Female Mice

08-15-2023

“Our findings highlight key molecular signatures and pathways in contracted muscle [...] that may contribute to skeletal muscle strength loss due to estrogen deficiency.”

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BUFFALO, NY- August 15, 2023 – A new research paper was published on the cover of Aging (listed by …

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A Novel Theory of Aging — Independent of Damage Accumulation

08-09-2023

“We argue that in multicellular organisms, neighbouring cells are in constant competition.”

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BUFFALO, NY- August 9, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, …

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Inhibiting NLRP3 Signaling in Aging Podocytes Improves Longevity

08-08-2023

“Together, these results suggest a critical role for the NLRP3 inflammasome in podocyte and liver aging.”

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BUFFALO, NY- August 8, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume …

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Towards Disease-Oriented Dosing of Rapamycin for Longevity

08-02-2023

"To understand a sum of quasi-programs (aging), we need to study early-life hyperfunctions."

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BUFFALO, NY- August 2, 2023 – A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, …

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Human Senescent Fibroblasts Cause Lung Fibrosis in Mice

07-31-2023

“These observations support that accumulation of senescent cells may contribute to fibrotic lung disease [...]”

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BUFFALO, NY- July 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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Predicting Lifespan-Extending Chemical Compounds for C. Elegans With Machine Learning

07-26-2023

“We created datasets for predicting whether or not a compound extends the lifespan of C. elegans [...]”

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BUFFALO, NY- July 26, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, …

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MSK1’s Required Role in Cognitive Benefits from Enriched Experiences in Old Age

07-25-2023

“We show that MSK1 retains its importance in converting positive experience into tangible synaptic and cognitive benefits well into old age [...]”

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BUFFALO, NY- July 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …

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Cognitive Rescue in Aging Through Prior Training

07-19-2023

“Prior training shows profound benefits in cognitive aging [...]”

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BUFFALO, NY- July 19, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, “Cognitive rescue …

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BUB1 Regulates EGFR Signaling by Reducing EGFR Internalization

07-17-2023

“We postulate that these observations may provide novel opportunities for therapeutic interventions for EGFR driven cancers.”

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BUFFALO, NY- July 17, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web …

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The Memtrax Continuous Recognition Test for Advanced Cognitive Impairment Screening

07-13-2023

“[...] MemTrax quickly demonstrates and quantifies the pertinent memory dysfunction of Alzheimer’s disease.”

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BUFFALO, NY- July 13, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume…

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NEW STUDY: Discovery of Chemical Means to Reverse Aging and Restore Cellular Function

07-12-2023

On July 12, 2023, a new priority research paper was published in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”

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BUFFALO, NY- July 12, 2023 – In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and …

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Hepatic Hydrogen Sulfide Levels are Reduced in Mouse Model of Progeria

07-11-2023

“To date, no studies have directly measured [hydrogen sulfide] production in Hutchinson-Gilford Progeria Syndrome [...]”

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BUFFALO, NY- July 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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A Novel Peptide ‘T14’ Reflects Age and Photo-Aging in Human Skin

07-05-2023

“[...] the results suggest a possible novel approach [for] exploring skin disorders [...]”

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BUFFALO, NY- July 5, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, …

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Age Prediction From Human Blood Plasma Using Proteomic and Small RNA Data: A Comparative Analysis

06-30-2023

“[...] we see our work as an indication that combining different molecular data types could be a general strategy to improve future aging clocks.”

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BUFFALO, NY- June 30, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging …

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Senescence and Senotherapies in Biliary Atresia and Biliary Cirrhosis

06-28-2023

“Our data provide the first integrative report about premature senescence in pediatric [biliary atresia] [...]”

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BUFFALO, NY- June 28, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volu…

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Methionine Restriction Reverses Old-age Obesity in Mice

06-27-2023

“This is the first report that showed the efficacy of methionine restriction to reverse old-age-induced obesity.”

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BUFFALO, NY- June 27, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Vo…

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Precious1GPT: Multimodal Transfer Learning for Aging Clock Development and Target Discovery

06-20-2023

“The development of Precious1GPT [...] has demonstrated the potential of our approach in deciphering the molecular mechanisms of aging.”

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BUFFALO, NY- June 20, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …

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Aging Sponsors 2023 Ride for Roswell

06-19-2023

Aging's publisher, Impact Journals, is sponsoring Team Open Access in the annual cycling event to end cancer: The Ride for Roswell. This fundraiser is hosted by Roswell Park Comprehensive Cancer Center in Buffalo, New York.

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BUFFALO, NY- June 19, 2023 – The Ride for …

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Short Telomeres in Alveolar Type II Cells Associate With Lung Fibrosis in Post COVID-19 Patients With Cancer

06-15-2023

“[...] here we reveal a link between short telomere length in ATII cells and post-viral lung fibrosis outcome in post-COVID-19 patients.”

BUFFALO, NY- June 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, …

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Cellular Senescence Involves Gene Repression Through p53-p16/RB-E2F-DREAM Complex

06-13-2023

“Our study enables us to envisage a global picture of genes and pathways dysregulated during senescence and provides novel evidence for involvement of p53/p16/RB-E2F-DREAM repressional targets in this complex cellular process.”

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BUFFALO, NY- June 13, 2023 – A new research …

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DNAmFitAge: Biological Age Indicator Incorporating Physical Fitness

06-07-2023

“We expect DNAmFitAge will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions.”

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BUFFALO, NY- June 7, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …

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Stress Granules Control Alzheimer's Gene Transcripts and Neuronal Proteostasis

06-01-2023

“Determining the mechanism underlying RNA sequestration in [stress granules] [...] could represent a key goal in the discovery and development of suitable [Alzheimer’s disease] biomarkers and therapies.”

BUFFALO, NY- June 1, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …

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External Factors Shape Genetic Predisposition to Lipids, Alzheimer’s and Heart Disease in MLXIPL Gene

05-24-2023

“Recent findings suggest that neurodegenerative and cardiovascular diseases may have overlapping etiologies [...]”

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BUFFALO, NY- May 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Vo…

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The Aging Mouse Prostate: Kinetics of Lymphocyte Infiltration

05-23-2023

“This dataset presents the most comprehensive profiling of the aging adult mouse prostate immune profile to date.”

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BUFFALO, NY- May 23, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Vo…

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Aging (Aging-US) at SSP 45th Annual Meeting

05-17-2023

Impact Journals (Aging's publisher) is proud to participate at the Society for Scholarly Publishing (SSP) 45th Annual Meeting, which convenes May 31–June 2, 2023, in Portland, Oregon.

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BUFFALO, NY-May 17, 2023 – Impact Journals (Aging's publisher) will be participating as …

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Musashi 1 in Breast Cancer: Implications for Dormancy and Survival in Bone Marrow

05-16-2023

“This study now links Msi 1 to PD-L1.”

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BUFFALO, NY- May 16, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Increased expression of musashi 1 on breast …

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Effects of Zoledronic Acid on Senescence and SASP Markers

05-15-2023

“In the present study, we used multiple complementary approaches to evaluate the possible effects of zoledronic acid on cellular senescence.”

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BUFFALO, NY- May 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany …

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The Senescence-Associated Secretory Phenotype Induces Neuroendocrine Transdifferentiation

05-12-2023

“We recently unveiled a new interesting role for SASP: its ability to induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells [3].”

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BUFFALO, NY- May 12, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging …

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An Epigenetic Approach to Modulating Aging With Nutrition and Exercise

05-10-2023

“In this review, we describe how aging impacts epigenetics and how nutrition and physical exercise can positively impact the aging process, from an epigenetic point of view.”

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BUFFALO, NY- May 10, 2023 – A new review paper was published in Aging (listed by MEDLINE/PubMed …

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Single-Cell Transcriptomic Analysis Uncovers Diverse and Dynamic Senescent Cell Populations

05-09-2023

“In summary, single-cell transcriptomic analysis has allowed us to identify the specific populations and the dynamic transition states during senescence initiation and progression.”

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BUFFALO, NY- May 9, 2023 – A new research paper was published in Aging (listed by …

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Dual-Purpose Therapeutic Targets for Aging and Glioblastoma Identified with PandaOmics

05-02-2023

“[...] AI-powered algorithms, such as PandaOmics, may accelerate subsequent gene target discovery not only for GBM but for a broader range of age-associated diseases.”

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BUFFALO, NY- May 2, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as …

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A Chronic Wound Model to Investigate Skin Cellular Senescence

05-01-2023

“Here, we report a chronic wound healing model that can be used to decipher the paradoxical role of cellular senescence in acute versus chronic wound healing.”

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BUFFALO, NY- May 1, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed …

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Effect of Deferoxamine and Ferrostatin-1 on Salivary Gland Dysfunction in Ovariectomized Rats

04-26-2023

“[...] this study is expected to be helpful in [...] developing a treatment for postmenopausal dry mouth.”

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BUFFALO, NY- April 26, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume …

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Characterization of the HDAC/PI3K Inhibitor CUDC-907 as a Novel Senolytic

04-25-2023

“The mechanisms of induction of senescent cell death by CUDC-907 remain to be fully elucidated.”

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BUFFALO, NY- April 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 7

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Serine Racemase Upregulation Improves Learning and Synaptic Function

04-19-2023

“The results from this study support the beneficial effects of the D-serine pathway involvement in NMDAR-mediated transmission and cognitive function [...]”

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BUFFALO, NY- April 19, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging …

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p21 Facilitates Chronic Lung Inflammation via Epithelial and Endothelial Cells

04-17-2023

“Our results implicate p21 as a critical regulator of chronic bronchitis and a driver of chronic airway inflammation and lung destruction.”

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BUFFALO, NY- April 17, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany …

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Selenium as a Predictor of Metabolic Syndrome in Middle Age Women

04-12-2023

“Recently, optimizing selenium intake in the population to prevent diseases [...] has been an important issue in modern health care worldwide.”

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BUFFALO, NY- April 12, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and …

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Knockout of AMD-Associated Gene POLDIP2 Reduces Mitochondrial Superoxide in Retinal Cells

04-11-2023

“To our knowledge, this is the first functional study of POLDIP2 in retinal cells to understand its potential role in AMD.”

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BUFFALO, NY- April 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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Aging at AACR Annual Meeting 2023

04-04-2023

Impact Journals (Aging's publisher) is proud to participate at the American Association for Cancer Research (AACR) Annual Meeting 2023, which convenes April 14-19 in Orlando, Florida.

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BUFFALO, NY-April 4, 2023 – Impact Journals will be participating as an exhibitor at …

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Diet/Lifestyle Program Reverses Biological Age: A Female Case Series

04-03-2023

“[...] these data suggest that a methylation-supportive diet and lifestyle intervention may favorably influence biological age in both sexes during middle age and older.”

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BUFFALO, NY- April 3, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed …

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Metformin & Leucine Prevent Cellular Senescence & Proteostasis Disruption

03-31-2023

“Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.”

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BUFFALO, NY- March 31, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" …

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Senescence and Extracellular Vesicles: Novel Partners in Vascular Amyloidosis

03-29-2023

“[...] there has been limited research to date on the effect of cellular ‘ageing’, termed senescence, on amyloidosis.”

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BUFFALO, NY- March 29, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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Parsing Chronological and Biological Age Effects on Vaccine Responses

03-27-2023

“Ultimately, while both chronological and biological age appear to be important determinants of vaccine-preventable outcomes in older adults, the underlying context and mechanisms of their effects remain unclear.”

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BUFFALO, NY- March 27, 2023 – A new editorial paper was …

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Age-Related Methylation Changes in the Human Sperm Epigenome

03-21-2023

“[...] we identified > 1,000 candidate genes with genome-wide significant age-related methylation changes in sperm.”

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BUFFALO, NY- March 21, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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Senescence-Associated Exosomes Transfer Fibrosis to Neighboring Cells

03-17-2023

“This shows that SA-EXOs can serve as potent SASP mediators that activate invasive characteristics in neighboring cells.”

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BUFFALO, NY- March 17, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of …

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AAV1.NT-3 Gene Therapy Prevents Age-Related Sarcopenia

03-15-2023

“Considering the cost and quality of life to the individual, we believe our study has important implications for management of age-related sarcopenia.”

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BUFFALO, NY- March 15, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as …

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Cognitive Aging and Dementia Prevention: The Time for Psychology?

03-10-2023

“[...] there is a need to explore brain mechanisms through which psychological processes may exert their protective or deleterious effects.”

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BUFFALO, NY- March 10, 2023 – Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) published a …

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Isoform-Specific AMPK Repression Affects Cognitive Function in Aged Mice

03-07-2023

“The study indicates that the aging process might have distinct impact on the signaling pathways associated with the AMPKα isoforms [...]”

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BUFFALO, NY- March 7, 2023 – Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) published a …

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Cellular Senescence: When Growth Stimulation Meets Cell Cycle Arrest

03-02-2023

“Growth and aging are driven by overlapping signaling pathways.”

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BUFFALO, NY- March 2, 2023 – Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) published a new review paper in Volume 15, Issue 4, entitled, “Cellular senescence: when …

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Telomere Shortening Linked to Depression and Cognitive Impairment in Older Adults

02-28-2023

“[...] we believe that our findings will help prevent and treat depression and cognitive impairment in the healthy elderly.”

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BUFFALO, NY- February 28, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and …

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Metformin's Impact on Aging and Longevity Through DNA Methylation

02-22-2023

“In this study, we compared genome-wide DNA methylation rates among metformin users and nonusers [...]”

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BUFFALO, NY- February 22, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume …

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Epigenetic Age and Lung Cancer Risk in the CLUE II Prospective Cohort Study

02-16-2023

“In this nested case-control study on incident lung cancer, we observed no positive associations between lung cancer risk and epigenetic age acceleration [...]”

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BUFFALO, NY- February 16, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by …

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Immune-Mediated Platelet Depletion Augments Alzheimer’s Disease in Mice

02-15-2023

“Our study suggests that platelets might contribute to limiting amyloid plaque size and neuronal damage, having a beneficial role in AD [Alzheimer’s disease].”

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BUFFALO, NY- February 15, 2023 – A new research paper was published on the cover of Aging (listed as "Aging …

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Body Weight Influences Musculoskeletal Adaptation to Running in Aging Mice

02-08-2023

“[...] [voluntary wheel running] differentially alters bone parameters depending on body weight [...]”

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BUFFALO, NY- February 8, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume …

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Are Menopause, Aging and Prostate Cancer Diseases?

02-02-2023

“Aging can be understood through the development of all quasi-programmed diseases.”

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BUFFALO, NY- February 2, 2023 – A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, …

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Clearance of p16Ink4a+ Cells: Limited Effects on β-Cell Mass and Proliferation in Mice

01-31-2023

“[...] we set out to explore the effects of removing p16Ink4a+ senescent cells on the proliferative capacity and mass of β-cells [...].”

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BUFFALO, NY- January 31, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by …

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The Innate Immune Signaling Component FBXC-58 Mediates Dietary Restriction Effects on Healthy Aging in Caenorhabditis elegans

01-25-2023

“In this study, we found that DR prevents muscle aging via fbxc-58 in C. elegans.”

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BUFFALO, NY- January 25, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 1, entitled, …

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Genetic Deficiency and Pharmacological Modulation of RORα Regulate Laser-Induced Choroidal Neovascularization

01-18-2023

“In this study, we present findings for a protective role of RORα in a mouse laser-induced CNV model of neovascular AMD.”

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BUFFALO, NY- January 18, 2023 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of …

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Single-Cell Transcriptomics of Peripheral Blood in the Aging Mouse

01-16-2023

“Here, we profiled 14588 single cells from the mouse blood and assessed the differences between young and old mice.”

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BUFFALO, NY- January 16, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" …

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Transcriptomic Analysis of Human ALS Skeletal Muscle Reveals Disease-Specific Pattern of Dysregulated circRNAs

01-12-2023

“In this work, we have identified distinct patterns of circRNA expression in human ALS muscle tissue, many appearing to be disease-specific, that display expression gradients at different levels within the CNS.”

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BUFFALO, NY- January 12, 2023 – A new research paper was …

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Epigenetic Aging Associated With Aberrant Neural Oscillatory Dynamics Serving Visuospatial Processing in People With HIV

01-05-2023

“Thus, these findings are the first to identify the interaction between biological age and HIV status on neural oscillatory dynamics serving cognitive function, and more specifically, visuospatial processing.”

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BUFFALO, NY- January 5, 2023 – A new research paper was …

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Associations of APOE ε2 and ε4 Alleles and Polygenic Profiles Comprising APOE-TOMM40-APOC1 Variants With Alzheimer’s Disease Biomarkers

01-03-2023

“The thickness of the arrows denotes tighter (thick lines) and weaker (thin lines) links between genetic variants, AD biomarkers, and cognitive impairment.”

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BUFFALO, NY- January 3, 2023 – A new research paper was published on the cover of Aging (listed as "Aging (Albany …

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