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​​Aging-US: Nutraceutical effects of Emblica officinalis


Aging-US published a Special Collection on Eye Disease which included "Nutraceutical effects of Emblica officinalis in age-related macular degeneration" which reported that EO has been used extensively as a nutraceutical in several diseases since it is known to boost immunity and offers numerous health benefits such as antioxidant, anti-inflammatory, and anti-aging effects.

AMD RPE transmitochondrial cell lines were created by fusion of mitochondria DNA-deficient APRE-19 (Rho0) cells with platelets isolated from AMD patients. EO significantly improved live cell number and mitochondrial membrane potential, reduced apoptosis and oxidative stress, down-regulated VEGF, and up-regulated PGC-1α.

Dr. M. Cristina Kenney from The University of California Irvine said, "Emblicaofficinalis Gaetrn (Phyllanthus emblica), commonly known as Indian gooseberry or Amla, is an edible fruit which is borne on a deciduous tree of the same name."

All parts of the Emblicaofficinalis (EO) tree i.e, fruits, bark, leaves, seeds, flowers, and roots are known to have medicinal properties. EO is native to the tropical and subtropical regions of Southeast Asia including India, China, Malaysia, Bangladesh, Sri Lanka, and Mascarene Island. Phytochemically it is composed of several bioactive compounds such as flavonoids, phenolic compounds, tannins, amino acids, cellulose, gum, and albumin.

All parts of the Emblicaofficinalis (EO) tree i.e, fruits, bark, leaves, seeds, flowers, and roots are known to have medicinal properties.

It is well-known as an immunity boosting food due to its high Vitamin C content which on an average is ~600 mg/100 g.

Figure 7. Effect of EO on VEGF gene expression and on cell viability and ROS levels in amyloid-β-stressed AMD cells. This figure showed down-regulation of VEGF gene in EO-treated AMD cybrids (A). Pretreatment with EO rescued AMD cybrids from amyloid-β-induced damage as shown by changes in cell viability (B (bar 2 versus bar 5) and ROS levels (C (bar 2 versus bar 5). *, **, and *** indicate p<0.05, p<0.01, and p<0.001 respectively; ns indicates non-significant p-value. Data are presented as mean ± SEM and normalized to untreated AMD cybrids which were assigned a value of 1.

The Kenney Research Team concluded in their Aging-US Research Output, "treatment with purified EO extract preserves mitochondrial and cellular health and function in human AMD RPE cybrids, implying that EO mitigates aging-related damage in AMD. Since EO extract is an over-the-counter nutraceutical and is available in both liquid and capsule forms for easy consumption, it might serve as an effective, inexpensive, and non-invasive therapeutic option for treatment of AMD. Further studies are required to fully understand the precise mechanisms that orchestrate the protective events post EO treatment in AMD cells."

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Correspondence to: M. Cristina Kenney email:

Keywords: Emblica officinalis, Phyllanthus emblica, Indian gooseberry, Amla, nutraceutical, age-related macular degeneration, AMD

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways.

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