Aging-US: p62/SQSTM1 coding plasmid prevents age related macular degeneration
09-08-2021Aging-US published a Special Collection on Eye Disease which included "p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model" which reported that P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies.
In retinal pigment epithelium (RPE), p62DNA administration slowed down development of destructive alterations of RPE cells, including loss of regular hexagonal shape, hypertrophy, and multinucleation. In neuroretina, p 62DNA prevented gliosis, retinal thinning, and significantly inhibited microglia/macrophages migration to the outer retina. Taken together, these results suggest that the p62 DNA has a strong retinoprotective effect in AMD.
These results suggest that the p62 DNA has a strong retinoprotective effect in AMD
Dr. Alexander Shneider and Dr. Nataliya Kolosova said, "Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in industrialized countries."
AMD is a multifactorial disease involving a complex interplay of genetic, environmental, metabolic, and functional factors. There are effective treatments of vascular complications of AMD by anti-VEGF therapeutics.
Figure 6. p62 (SQSTM1) as a mediator of several pathways. Anti-inflammatory effect of p62 can be mediated via inhibition of NF-kB pathway as well as antioxidant response and clearance of damaged proteins/organelles (e.g., mitochondria) [25–28].
Retinopathy that develops in OXYS rats even at a young age corresponds (in terms of clinical manifestations and morphological characteristics) to the dry atrophic form of AMD in humans.
The Shneider/Kolosova Research Team concluded in their Aging-US Research Output, "our data suggests that a p62-encoding plasmid might be a novel preventive and/or therapeutic agent for AMD as it maintained retinal thickness and restored RPE morphology."
Full Text - https://www.aging-us.com/article/101537/text
Correspondence to: Alexander Shneider email: ashneider@curelab.com and Nataliya Kolosova email: kolosova@bionet.nsc.ru
Keywords: p62/SQSTM1, age-related macular degeneration, inflammation, gliosis, OXYS rats, aging, retina
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Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
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