The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis


Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy.

Dr. Gustavo Duque from the Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia and the Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia said, "Marrow adipose tissue accumulation and the associated marrow lipotoxicity has been suggested as a major cause of bone and red marrow volume decline in humans and animals"

MAT accumulation, which occurs at the expense of bone and hematopoietic bone marrow, is associated with decreased bone formation at the proximity of MAT, and declined bone mechanical strength.

To study the possible roles of MAT in the reported bone mass preservation associated with the supplementation of fatty acids we measured bone, MAT and HBM in the femoral bones of SAMP8 mice.

The Duque Research team concluded, "In conclusion, this study provides further evidence on the possible roles of MAT expansion in the progression of age-related bone loss and anemia via the lipotoxic effects of MAT on bone and HBM in aging mice."

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Correspondence to: Gustavo Duque email:

Keywords: aging, fish oil, marrow adipose tissue, osteoporosis, SAMP8 mouse

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Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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