The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy.

Dr. Gustavo Duque from the Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia and the Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia said, "Marrow adipose tissue accumulation and the associated marrow lipotoxicity has been suggested as a major cause of bone and red marrow volume decline in humans and animals"

MAT accumulation, which occurs at the expense of bone and hematopoietic bone marrow, is associated with decreased bone formation at the proximity of MAT, and declined bone mechanical strength.

To study the possible roles of MAT in the reported bone mass preservation associated with the supplementation of fatty acids we measured bone, MAT and HBM in the femoral bones of SAMP8 mice.

The Duque Research team concluded, "In conclusion, this study provides further evidence on the possible roles of MAT expansion in the progression of age-related bone loss and anemia via the lipotoxic effects of MAT on bone and HBM in aging mice."

Full Text - https://www.aging-us.com/article/102299/text

Correspondence to: Gustavo Duque email: gustavo.duque@unimelb.edu.au

Keywords: aging, fish oil, marrow adipose tissue, osteoporosis, SAMP8 mouse