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Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

10-02-2019

Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy.

Dr. Gustavo Duque from the Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia and the Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia said, "Marrow adipose tissue accumulation and the associated marrow lipotoxicity has been suggested as a major cause of bone and red marrow volume decline in humans and animals"

MAT accumulation, which occurs at the expense of bone and hematopoietic bone marrow, is associated with decreased bone formation at the proximity of MAT, and declined bone mechanical strength.

To study the possible roles of MAT in the reported bone mass preservation associated with the supplementation of fatty acids we measured bone, MAT and HBM in the femoral bones of SAMP8 mice.

The Duque Research team concluded, "In conclusion, this study provides further evidence on the possible roles of MAT expansion in the progression of age-related bone loss and anemia via the lipotoxic effects of MAT on bone and HBM in aging mice."

Full Text - https://www.aging-us.com/article/102299/text

Correspondence to: Gustavo Duque email: gustavo.duque@unimelb.edu.au

Keywords: aging, fish oil, marrow adipose tissue, osteoporosis, SAMP8 mouse

**About Aging-US:**

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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