Research Perspective Volume 2, Issue 2 pp 101—106
Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?
- 1 Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, CH-1005, Switzerland
- 2 CNRS, UMR 5203, Institut de Génomique Fonctionnelle, 34094 Montpellier, France
received: February 9, 2010 ; accepted: February 16, 2010 ; published: February 17, 2010 ;https://doi.org/10.18632/aging.100123
How to Cite
By regulating the metabolism of fatty acids, carbohydrates, and xenobiotic, the mammalian circadian clock plays a fundamental role on the liver physiology. At present, it is supposed that the circadian clock regulates metabolism mostly by regulating the expression of liver enzymes at the transcriptional level. However, recent evidences suggest that some signaling pathways synchronized by the circadian clock can also influence metabolism at a post-transcriptional level. In this context, we have recently shown that the circadian clock synchronizes the rhythmic activation of the IRE1α pathway in the endoplasmic reticulum. The absence of circadian clock perturbs this secondary clock, provokes deregulation of endoplasmic reticulum-localized enzymes, and leads to impaired lipid metabolism. We will describe here the additional pathways synchronized by the clock and discussed the influence of the circadian clock-controlled feeding rhythm on them.