Hypothesis Volume 2, Issue 5 pp 265—273
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
- 1 Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Received: February 1, 2010 Accepted: May 14, 2010 Published: May 15, 2010https://doi.org/10.18632/aging.100149
How to Cite
Women live longer than men. Yet, it is believed that men do not age faster than women but simply are weaker at every age. In contrast, I discuss that men age faster. From evolutionary perspective, high accidental death rate in young males is compatible with fast aging. Mechanistically, hyper-activated mTOR (Target of Rapamycin) may render young males robust at the cost of accelerated aging. But if women age slower, why then is it women who have menopause? Some believe that menopause is programmed and purposeful (grandmother theory). In contrast, I discuss how menopause is not programmed but rather is an aimless continuation of the same program that initially starts reproduction at puberty. This quasi-program causes over-activation of female reproductive system, which is very vulnerable to over-activation. Mechanisms of aging and menopause are discussed.