Research Perspective Volume 3, Issue 3 pp 304—310
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
- 1 Division of Molecular and Life Science
- 2 School of Interdisciplinary Bioscience and Bioengineering
- 3 World Class University Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Kyungbuk, 790-784, South Korea
Received: February 26, 2011 Accepted: March 6, 2011 Published: March 6, 2011
https://doi.org/10.18632/aging.100292How to Cite
Abstract
A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration.