Review Volume 3, Issue 5 pp 494—508
The promise of human embryonic stem cells in aging-associated diseases
- 1 Cardiovascular Research Institute, San Francisco, CA 94143 USA
- 2 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143 USA
- 3 Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 USA
received: April 24, 2011 ; accepted: May 9, 2011 ; published: May 11, 2011 ;https://doi.org/10.18632/aging.100328
How to Cite
Aging-associated diseases are often caused by progressive loss or dysfunction of cells that ultimately affect the overall function of tissues and organs. Successful treatment of these diseases could benefit from cell-based therapy that would regenerate lost cells or otherwise restore tissue function. Human embryonic stem cells (hESCs) promise to be an important therapeutic candidate in treating aging-associated diseases due to their unique capacity for self-renewal and pluripotency. To date, there are numerous hESC lines that have been developed and characterized. We will discuss how hESC lines are derived, their molecular and cellular properties, and how their ability to differentiate into all three embryonic germ layers is determined. We will also outline the methods currently employed to direct their differentiation into populations of tissue-specific, functional cells. Finally, we will highlight the general challenges that must be overcome and the strategies being developed to generate highly-purified hESC-derived cell populations that can safely be used for clinical applications.