Research Perspective Volume 3, Issue 7 pp 685—691
Progeria, rapamycin and normal aging: recent breakthrough
- 1 Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY, 14263, USA
Received: July 5, 2011 Accepted: July 7, 2011 Published: July 8, 2011https://doi.org/10.18632/aging.100352
How to Cite
A recent discovery that rapamycin suppresses a pro-senescent phenotype in progeric cells not only suggests a non-toxic therapy for progeria but also implies its similarity with normal aging. For one, rapamycin is also known to suppress aging of regular human cells. Here I discuss four potential scenarios, comparing progeria with both normal and accelerated aging. This reveals further indications of rapamycin both for accelerated aging in obese and for progeria.