Review Volume 6, Issue 6 pp 432—439
Aging and DNA damage in humans: a meta-analysis study
- 1 CIDESD, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- 2 University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- 3 Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway
- 4 CECAV - Genetic and Biotechnology Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
received: April 5, 2014 ; accepted: June 2, 2014 ; published: June 5, 2014 ;https://doi.org/10.18632/aging.100667
How to Cite
Age-related DNA damage is regarded as one of the possible explanations of aging. Although a generalized idea about the accumulation of DNA damage with age exists, results found in the literature are inconsistent. To better understand the question of age-related DNA damage in humans and to identify possible moderator variables, a meta-analysis was conducted.
Electronic databases and bibliographies for studies published since 2004 were searched. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for age-related DNA damage were calculated in a random-effects model.
A total of 76 correlations from 36 studies with 4676 participants were included. Based on our analysis, a correlation between age and DNA damage was found (r = 0.230, p = 0.000; 95% confidence interval = 0.111 - 0.342). The test for heterogeneity of variance indicates that the study´s results are significantly high (Q (75) = 1754.831, p = 0.000). Moderator variables such as smoking habits, technique used, and the tissue/sample analyzed, are shown to influence age-related DNA damage (p=0.026; p=0.000; p=0.000, respectively). Nevertheless, sex did not show any influence on this relation (p=0.114).
In conclusion, this meta-analysis showed an association between age and DNA damage in humans. It was also found that smoking habits, the technique used, and tissue/sample analyzed, are important moderator variables in age-related DNA damage.