Research Paper Volume 10, Issue 7 pp 1586—1596
Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo
- 1 Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China
- 2 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
- 3 Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
- 4 University of Chinese Academy of Sciences, Beijing 100101, China
received: April 8, 2018 ; accepted: July 5, 2018 ; published: July 23, 2018 ;https://doi.org/10.18632/aging.101494
How to Cite
Copyright: Liang et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
After ovulation, metaphase II oocytes undergo a time-dependent deterioration in vivo or in vitro, which is referred to as postovulatory oocyte aging, a process during which a series of deleterious molecular and cellular changes occur. In this study, we found that short-term injection of resveratrol (3,5,4'-trihydroxystilbene) effectively ameliorated oxidative stress-induced damage in postovulatory oocyte aging of middle-aged mice in vivo. Resveratrol induced changes that delayed the aging-induced oocyte deterioration including the elevated expression of the anti-aging molecule Sirtuin 1 (SIRT1); it reduced intracellular reactive oxygen species (ROS) level, and improved mitochondria function. In addition, these beneficial changes may also help to prevent apoptosis. Taken together, our data suggest that resveratrol can effectively protect against postovulatory oocyte aging in vivo primarily by preventing ROS production.