Research Paper Volume 11, Issue 5 pp 1524—1536
Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia
- 1 Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin 71-210, Poland
- 2 Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Szczecin 71-210, Poland
- 3 Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin 71-460, Poland
- 4 Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin 70-111, Poland
- 5 Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University, Szczecin 71-210, Poland
Received: November 15, 2018 Accepted: March 3, 2019 Published: March 13, 2019
https://doi.org/10.18632/aging.101850How to Cite
Abstract
The purpose of our investigation was to analyze the relationship between the serum levels of fatty acids and their metabolites and the levels of the selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). We determined serum concentrations of total (TT) and free testosterone (FT), insulin (I), dehydroepiandrosterone sulphate (DHEAS), luteinizing hormone and insulin-like growth factor 1 (IGF-1) and sex hormone-binding globulin (SHBG). Gas chromatography was performed. The patients differed in terms of hormone levels, but only the differences in SHBG and IGF-1 levels were statistically significant. Analysis of the levels of polysaturated fatty acids in BPH patients showed that MetS contributed to changes in the levels of these acids. We also analyzed the relationship between the levels of fatty acids and diagnostic parameters for MetS. Particular abnormalities were associated with single changes in the levels of fatty acids. In the diabetic patients, changes in the levels of pentadecanoic acid, heptadecanoic acid and cis-11-eicosenoic acid were demonstrated. Our findings indicate the necessity for further investigation concerning the levels of fatty acids and their impact on the development of MetS, as well as the course and clinical picture of BPH.