Research Paper Volume 11, Issue 12 pp 4216—4237
β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid
- 1 School of Integrative and Global Majors (SIGMA) University of Tsukuba, Tsukuba City, 305-8572, Japan
- 2 Faculty of Life and Environmental Sciences University of Tsukuba, Tsukuba City, 305-8572, Japan
- 3 Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba, Tsukuba City, 305-8572, Japan
received: April 23, 2018 ; accepted: June 17, 2019 ; published: June 29, 2019 ;https://doi.org/10.18632/aging.102048
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Copyright: Bejaoui et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The hair follicle is a complex structure that goes through a cyclic period of growth (anagen), regression (catagen), and rest (telogen) under the regulation of several signaling pathways, including Wnt/ β-catenin, FGF, Shh, and Notch. The Wnt/β-catenin signaling is specifically involved in hair follicle morphogenesis, regeneration, and growth. β-catenin is expressed in the dermal papilla and promotes anagen induction and duration, as well as keratinocyte regulation and differentiation. In this study, we demonstrated the activation of β-catenin by a polyphenolic compound 3,4,5-tri-O-caffeoylquinic acid (TCQA) in mice model and in human dermal papilla cells to promote hair growth cycle. A complete regrowth of the shaved area of C3H mice was observed upon treatment with TCQA. Global gene expression analysis using microarray showed an upregulation in hair growth-associated genes. Moreover, the expression of β-catenin was remarkably upregulated in vivo and in vitro. These findings suggest that β-catenin activation by TCQA promoted the initiation of the anagen phase of the hair cycle.