Research Paper Volume 11, Issue 23 pp 10952—10991

Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990–2017: results from a global burden of disease study, 2017

Hui Sun 1, 2, *, , Ting-Ting Gong 3, *, , Yu-Ting Jiang 1, 2, , Shuang Zhang 1, 2, , Yu-Hong Zhao 1, 2, , Qi-Jun Wu 1, 2, ,

  • 1 Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China
  • 2 Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China
  • 3 Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
* Co-first authors

received: July 28, 2019 ; accepted: November 17, 2019 ; published: December 2, 2019 ;
How to Cite

Copyright © 2019 Sun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


To provide comprehensive estimates of the global, regional, and national burden of infertility from 1990 to 2017, using findings from a 2017 study on the global burden of disease (GBD), we assessed the burden of infertility in 195 countries and territories from 1990 to 2017. DisMod-MR 2.1 is a Bayesian meta-regression method that estimates non-fatal outcomes using sparse and heterogeneous epidemiological data. Globally, the age-standardized prevalence rate of infertility increased by 0.370% per year for females and 0.291% per year for males from 1990 to 2017. Additionally, age-standardized disability-adjusted life-years (DALYs) of infertility increased by 0.396% per year for females and 0.293% per year for males during the observational period. An increasing trend to these burden estimates was observed throughout the all socio-demographic index (SDI) countries. Interestingly, we found that high SDI countries had the lowest level of prevalence and DALYs in both genders. However, the largest increasing trend was observed in high-SDI countries for females. By contrast, low-SDI countries had the largest increasing trend in males. Negative associations were observed between these burden estimates and the SDI level. The global disease burden of infertility has been increasing throughout the period from 1990 to 2017.


DALYs: disability-adjusted life-years; SDI: sociodemographic index; GBD: global burden of disease; YLD: years of life lived with disability; YLL: years of life lost; APC: annual percentage change; CI: confidential interval; PC: percentage change.