Research Paper Volume 11, Issue 23 pp 11382—11390

Young age at diagnosis is associated with better prognosis in stage IV breast cancer

Wei Liu 1, *, , Xi-feng Xiong 2, *, , Yu-zhen Mo 3, , Wei-guang Chen 1, , Mei Li 1, , Rong Liang 1, , Zhi-biao Zhang 4, , Zhi Zhang 5, ,

  • 1 Department of Breast, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, China
  • 2 Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, China
  • 3 Department of Radiotherapy, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, China
  • 4 Department of Breast, Donghua Hospital of Dongguan, Dongguan, Guangdong 523110, China
  • 5 Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, China
* Equal contribution

received: September 7, 2019 ; accepted: November 18, 2019 ; published: December 11, 2019 ;

https://doi.org/10.18632/aging.102536
How to Cite

Copyright © 2019 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Numerous studies have shown that young age is a risk factor in early breast cancer. But for stage IV breast cancer, it is unclear whether age has a similar effect on patient survival. We collected and analyzed data from patients with stage IV breast cancer between January 2010 and December 2015 in SEER database. Multivariate Cox proportional hazard model was used in this study. 13,069 patients with stage IV breast cancer were included in the analysis, of which 1,135 were young breast cancer patients (≤40 years old). In a multivariate analysis that adjusted for sociodemographic factors, clinical-pathological characteristics and therapeutic methods, the risk of death in patients with stage IV ≤40 years was significantly reduced (hazard ratio [HR], 0.72; 95% CI, 0.65-0.79). Subgroup analyses showed that, with the same adjustment of all factors, young age only significantly reduced the risk of death in patients with luminal A (HR, 0.78; 95% CI, 0.68-0.89) and luminal B (HR 0.46; 95% CI, 0.35-0.60) subtypes. Young age at diagnosis is associated with better survival in patients with stage IV breast cancer. The effect of young age at diagnosis on the survival outcome of stage IV breast cancer varies by subtypes.

Abbreviations

SEER: Surveillance, Epidemiology, and End Results; HR: Hazard Ratio; CI: confidence interval; AJCC: American Joint Committee on Cancer; ER: Estrogen Receptor; PR: Progesterone Receptor; HER2: Human Epidermal Growth Factor Receptor 2; W: White; B: Black; AI: American Indian/Alaska Native; API: Asian or Pacific Islander.